Pinyin: Mǔ Dān Pí
Alias:Danpi, powder Danpi, Mushaoyao, striped Danpi, Luoyang flower
English name:CORTEX MOUTAN
Source:
This herb is the dry root bark of the ranunculaceae peony, Paeonia suffruticosa Andr. In autumn, the roots are excavated, the fine roots are removed, the root bark is peeled off, and dried in the sun.
Properties
This product is cylindrical or semi-cylindrical, with longitudinally cut cracks, slightly curled or opened inward, 5-20 cm long, 0.5-1.2 cm in diameter, and 0.1-0.4 cm thick. The outer surface is gray-brown or yellow-brown, with many horizontally long lenticels and fine root scars, and the cork is pink at the shedding part.
The inner surface is light gray-yellow or light brown, with obvious fine vertical lines, and shiny crystals are common. Hard and brittle, easy to break, flat section, light pink, powdery. Gas aroma, taste slightly bitter and astringent.
Storage Store in a cool dry place.
Chemical composition
The root contains paeonol, paeonol glycosides, pro-paeonol glycosides, and paeoniflorin. It still contains 0.15-0.4% of volatile oil and phytosterols.
Pharmacological effects
① Effects on the central nervous system
Intraperitoneal injection or oral administration of paeonol in mice has sedative, hypnotic and analgesic effects; it reduces the body temperature of normal mice (intraperitoneal injection or gavage), and also has antipyretic effects on artificial fever mice (caused by injection of typhoid and paratyphoid bacilli). effect; also anti-electric shock or drug-induced shock effect
② antihypertensive effect
Intravenous injection of paeonol water decoction (equivalent to crude drug 0.75 g/kg) has antihypertensive effect on anesthetized dogs, cats and rats; paeonol and decoction from paeonol have also reduced blood pressure in acute animal experiments Efficacy; oral administration in experimental hypertensive (“primary” and renal) dogs or rats can have a certain antihypertensive effect, but the effect is slower, possibly due to slow absorption in the gastrointestinal tract.
③ Antibacterial effect
In the test tube, it has strong antibacterial effect on Staphylococcus albus, Bacillus subtilis, Escherichia coli and Typhoid Bacillus. Cortex Moutan has a significant effect on Shigella and Typhoid Bacillus (two-fold dilution method in test tube), and has the strongest bactericidal effect at pH 7.0 to 7.6. The agar plate trenching method has also been proved to be effective against typhoid bacillus, dysentery bacillus, parasitic cold bacillus, and Escherichia coli.
Proteus, Pseudomonas aeruginosa, Staphylococcus, hemolytic streptococcus, pneumococcus, Vibrio cholerae and other bacteria have different degrees of inhibition. Paeonol also has inhibitory effects on Escherichia coli, Bacillus subtilis, Staphylococcus aureus, etc. in test tubes. The infusion of paeonol also has a certain inhibitory effect on 10 kinds of dermatophytes such as Microbacillus rust in the test tube.
④Other functions
Paeonol has an inhibitory effect on the edema of hindlimb and plantar in rats, and can reduce the permeability of blood vessels. Experiments with chicken embryos show that Cortex Moutan has a certain antiviral effect, but the results are different when mice are given gavage and then infected with influenza virus, so its antiviral effect is still uncertain.
The hot infusion of Hima peony produced in the Himalayas has an excitatory effect on the uterus of various animals, but it inhibits the frog heart, and has an antispasmodic effect on the intestinal tract of rabbits and guinea pigs. The ethanolic extract of medicinal peony, steamed to remove ethanol, has a digitalis-like effect on the heart of frogs, can excite the uterus, inhibit the intestinal tract of rats and rabbits, and slightly reduce blood pressure in rats, but has no analgesic and anticonvulsant effects (electric shock). and pentamethyltetrazolium shock).
Processed peony bark: pick out impurities, remove the wood core, wash, moisten thoroughly, slice and dry. Stir-fried Danpi: Put the Danpi slices in a hot pot, stir-fry continuously until there is a slight yellow scorch spot, take the mountain and cool it thoroughly. Tan skin charcoal: Take the peony skin slices into the pot, fry them with strong fire until they are charred black, and the stability is the degree.
Identification
1) The powder of this product is light reddish brown. There are many starch granules, single granules are round or polygonal, 3-16 μm in diameter, umbilical point-shaped, crack-shaped or bird-shaped; complex granules are composed of 2-6 granules. Calcium oxalate clusters are 9-45 μm in diameter, and sometimes contain crystal cells connected, cluster crystals arranged in rows, or a cell contains several cluster crystals. Cork cells are oblong, slightly thick-walled, light red.
2) Take 0.15g of this product powder, add 25ml of absolute ethanol, shake for several minutes, and filter. Take 1ml of the filtrate, add anhydrous ethanol to 25ml, and measure it according to the spectrophotometric method (Appendix Ⅴ A). The maximum absorption is at the wavelength of 274nm.
3) Take 1g of this product powder, add 10ml of ether, seal it, shake for 10 minutes, filter, evaporate the filtrate to dryness, add 2ml of propylene copper to the residue to dissolve it, and use it as the test solution. Another reference substance of paeonol was taken, and acetone was added to make a solution containing 5mg per 1ml, as the reference substance solution. According to the thin-layer chromatography (Appendix VI B) test, draw 10 μl of each of the above two solutions, and spot them on the same silica gel G thin-layer plate respectively.
Use cyclohexane-ethyl acetate (3:1) as the developing agent to develop, Take it out, dry it, spray it with an acidic 5% ferric chloride ethanol solution of hydrochloric acid, and heat it until the spots become clear. In the chromatogram of the test substance, the same blue-brown spots were displayed on the corresponding position of the chromatogram of the reference substance.
Return to the heart, liver and kidney meridians.
Nature and taste Bitter, acrid, slightly cold.
Uses and indications
Clearing heat and cooling blood, promoting blood circulation and removing blood stasis. It is used for mild toxin, spotting, hematemesis and epistaxis, hot nights and early coolness, no sweating and bone steaming, amenorrhea, dysmenorrhea, carbuncles, swollen sores, and pain from falls.
Usage and dosage 6～12g.
Remarks
1) Cortex Moutan is good at clearing blood and promoting blood circulation, so it has the effect of cooling blood and dissipating blood stasis, making blood flow smoothly without leaving blood stasis, and clearing blood without rash action. Therefore, it is used as an essential medicine for the symptoms of fiery heat in the blood, exuberance of liver and kidney fire, and blockage of blood stasis. This product can clear heat and cool blood when matched with fresh raw ground; when combined with large raw ground, it can nourish kidney and purify fire; when combined with Shanzhi, it can clear liver and relieve heat; when combined with red peony root and peach kernel, it can promote blood circulation and disperse blood stasis; Cool blood to stop bleeding.
It is used for febrile diseases, heat entering the blood, high fever, dark tongue, rash on the body, blood heat, vomiting blood, epistaxis, hematuria, and fever due to yin deficiency. Cortex Moutan clears the real heat of the blood, and at the same time can cure the fever due to yin deficiency.
Clearing the blood is divided into real heat, and it is often used in the same way as Xianshengdi and Chishao; for the treatment of deficiency heat, it is often combined with Dashengdi, Anemarrhena, Artemisia annua, and turtle shells; Cypress leaves, mountain gardenia, etc. are used.
For amenorrhea, fall injury, sore carbuncle swollen poison, intestinal carbuncle embolism. Amenorrhea and injury all have stagnation of qi and blood, and pain often occurs due to stagnation of collaterals. Danpi can promote blood circulation and disperse blood stasis, make blood stasis and blood flow smooth, and relieve pain.
This product is also a commonly used drug for sore carbuncle swollen poison and intestinal carbuncle embolism. To treat sore carbuncle, it can be combined with heat-clearing and detoxifying drugs such as Yinhua, Forsythia, Didingcao, etc. For the treatment of intestinal carbuncle without pus at the beginning, it can be used with rhubarb, Glauber’s salt, peach kernel, winter melon seeds, etc.; , Forsythia, Baijiangcao and other applications.
Excerpt from “Chinese Pharmacopoeia”